Notably, treatment of T-47D breast cancer cells with 30 μM of α-mangostin resulted in reduced phosphorylation of HER-2 at the Tyr1221/1222 within 30 min, leading to the deactivation of RAS/RAF1/MEK/ERK and PI3K/AKT signaling pathways, and consequently, an anti-proliferative and pro-apoptotic effect (Fig. 3) [74]. Here, AKT1 is linked to breast carcinoma.