In line with experimental studies in mouse models of inflammatory diseases showing a pivotal role for CCR4 in mediating Treg migration to inflammatory tissues (Yuan et al., 2007; Faustino et al., 2013), we found that CCR4 expression on Tregs may be critical for their migration to the atherosclerotic aorta, providing a possible mechanism for CCR4-dependent regulation of atherosclerosis. The gene discussed is CCR4; the disease is atherosclerosis.