Interestingly, we found a trend toward reduction in the proportion of CCR4-deficient Kaede-expressing Tregs in the aorta of recipient Apoe-/- mice (Figure 5I), suggesting that CCR4-deficient Tregs may have a reduced ability to migrate to the atherosclerotic aorta, but not to the peripheral lymphoid tissues, under hypercholesterolemia. The gene discussed is APOE; the disease is familial hypercholesterolemia.