To provide direct evidence for the critical role of CCR4 expression in Tregs in reducing early atherosclerosis, we injected Apoe-/- mice with saline or Tregs from Apoe-/- or Ccr4-/-Apoe-/- mice and analyzed the aortic root atherosclerotic lesions of recipient Apoe-/- mice (Figure 6A). The gene discussed is APOE; the disease is atherosclerosis.