CCL17 and Atherosclerotic lesion: Although the disruption of the CCL17/CCL22–CCR4 axes did not affect the development of advanced atherosclerotic lesions or the proportion of Tregs in peripheral lymphoid tissues in atherosclerosis-prone mice fed a high-cholesterol diet (Weber et al., 2011; Döring et al., 2024), its effect on the early stage of atherosclerosis and Treg responses has not been investigated.