BUB1B and heart failure: Future studies incorporating functional longitudinal analysis by echocardiography and electrophysiological assessments in BubR1 hypomorphic hearts, or conditional BubR1 knockouts that lack BubR1 in the adult heart or within specific subsets of cardiomyocytes, would be useful to further validate these associations and determine the extent to which the transcriptomic changes reflect relevant pathophysiological phenotypes seen in the heart in response to aging and heart failure.