Pharmacologic and genetic approaches demonstrated that ligand-dependent activation of PPARδ leads to transcriptional changes that translate into functional alterations (Figs. 4 and 5), enabling tumor cells to (i) gain metabolic plasticity, allowing them to adapt and survive under challenging environmental conditions, and (ii) acquire mobility, facilitating their escape from the primary tumor to seek more favorable environments elsewhere. The gene discussed is PPARD; the disease is neoplasm.