NR1H4 and neoplasm: This study demonstrates that W. cibaria supplementation attenuates tumor burden in azoxymethane/dextran sulfate sodium (AOM/DSS)-induced CAC mice by orchestrating a triad of effects: restructuring gut microbiota to reduce Lactobacillaceae enrichment, reducing BSH activity and unconjugated BA accumulation, and activating intestinal FXR signaling to suppress NF-κB-driven inflammation.