NICOL1 and Intellectual disability: It is interesting to note that NICOL1, POLN and ZFYVE28 are in the OCU2 regions that include genes involved in the Wolf–Hirschhorn Syndrome (WHS), a rare human disorder characterised by a typical facial appearance called Greek warrior helmet facies, intellectual disability and growth delay, among others (Paradowska‐Stolarz, 2014).