It is important to note that the link between NUP153 and chemotherapy sensitivity is based on database correlation analysis, and the precise mechanism—such as whether it influences drug efflux via nuclear translocation—remains to be confirmed through experimental studies.In our study, X4.5-diamino-2-phthalimidobenzene (X4.5dianilinophthalimide, NAPH) and Imatinib were found to inhibit NUP153 expression in most cancers, providing new experimental evidence for chemotherapy drug selection. This evidence concerns the gene NUP153 and cancer.