SMAD4 and cancer: Figure 6A shows the distribution of the top five correlated functional proteins in various tumour tissues. In uveal melanoma (UVM), NUP153 expression was significantly positively correlated with SMAD4, CYCLINB1, and phosphorylated ERα (ERALPHA-ps118) protein levels, and negatively correlated with type VI collagen (collagen vi) and NRAS protein levels. Figure 6B displays the most significant functional proteins of NUP153 in UVM. We then constructed a relationship network between cancer and functional proteins (Figure 6C).