TNF and rheumatoid arthritis: KEGG analysis further highlighted that cluster 0 was involved in pathways such as Shigellosis, C-type lectin receptor signaling, TNF signaling, Salmonella infection, and NF-κB signaling, while cluster 1 was linked to Lysosome, Phagosome, Intestinal immune network for IgA production, Rheumatoid arthritis, and glycan degradation pathways.