An increase of CXCR3+CD8+ T cells and a localization around the portal tract was described in biliary atresia and adult primary biliary cholangitis (36, 37), while CXCR6+ cells are directed to the cholangiocytes by their respective ligand CXCL16 (27, 38). Here, CXCR3 is linked to biliary liver cirrhosis.