WikiPathways enrichment analysis identified ‘Canonical and non-canonical TGF-β signaling’ and ‘NRP1-triggered signaling pathways in pancreatic cancer’ as significantly enriched pathways, further indicating that these genes may participate in TGF-β-related signaling regulation, supporting the potential molecular mechanisms of fibrosis (S1B). The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.