Finally, comparative analysis between these scRNAseq data sets and with our in-house HFD ApoE-/- atherosclerosis mouse model bulk RNA-seq data set (Supplementary Table S1) was used to identify a novel MØ-specific STAT1-dependent integrated gene signature to monitor human atherosclerotic plaque formation (Figure 1). The gene discussed is APOE; the disease is atherosclerosis.