Interestingly, this correlated with MØ sub-type dependent STAT1 activity, as well as for STAT2, IRF4, IRF5, IRF8 and IRF9, and agrees with a known role of these TFs in atherosclerosis (55–59), suggesting the transcriptional collaboration of STAT1 with STAT2 and IRF family members, in the form of GAF, ISGF3 (STAT1,STAT2 and IRF9) and multiple IRFs, in these MØ subtypes. This evidence concerns the gene IRF4 and atherosclerosis.