The Pde6bnmf137 mice, carrying a missense mutation c.1976T>C, p.L659P (hereafter referred to as the Pde6b-L659P mutation) in the Pde6b gene, exhibit severe photoreceptor degeneration and serve as a valuable model for studying and treating retinal degeneration [18] (Fig. 1). This evidence concerns the gene PDE6B and retinal degeneration.