There was a significant association between positive immunoreactivities to matrix metalloproteinase-1 (AOR 5.40, 95% CI: 0.981-29.794, P: 0.044) and matrix metalloproteinase-9 (AOR: 6.205, 95% CI: 1.467-26.239, P: 0.013) with the appearance of pelvic organs prolapses in the city of Kananga. This evidence concerns the gene MMP1 and pelvic organ prolapse.