Additionally, anti-Act1 macrophages facilitate the benign-to-malignant transition in CRC cells via the CXCL9/10-CXC chemokine receptor 3 (CXCR3) axis and induce CD8+ T cell exhaustion through the PD-L1/PD-1 axis85. The gene discussed is CD8A; the disease is colorectal carcinoma.