OTU deubiquitinase 5 (OTUD5) and USP52 have been shown to stabilize SLC7A11 by removing its K48-linked polyubiquitination; however, the depletion of OTUD5 and USP52 sensitizes TNBC and bladder cancer to PTX and imidazole ketone erastin (IKE), respectively 50, 51. Here, OTUD5 is linked to urinary bladder cancer.