Guan et al. revealed that USP7 is capable of deubiquitinating SCD; conversely, the inhibition of SCD by DHPO (an allosteric site covalent inhibitor of USP7) not only induces ferroptosis but also exhibits superior antitumor efficacy without severe side effects compared with cisplatin in a gastric cancer PDX mouse model 24. This evidence concerns the gene USP7 and gastric cancer.