A study from Jinan University has reported that USP11 interacts with E2F1, maintaining the stability of E2F1 protein by deubiquitination, while E2F1 regulates the expression of USP11 at the transcriptional level, thus forming a positive feedback loop between E2F1/USP11 that promotes the proliferation and migration of HCC cells82. The gene discussed is USP11; the disease is hepatocellular carcinoma.