In the female cohort, the association between high AIP and the risk of prehypertension/hypertension increased from 1.49-fold (OR=1.49, 95% CI:1.14 to 1.95, P=0.003) in 2015 to 1.64-fold (OR=1.64, 95% CI:1.31 to 2.06, P<0.001) in 2018, with this trend being particularly pronounced among postmenopausal women. This evidence concerns the gene AIP and hypertensive disorder.