Additionally, genome-wide analyses reveal that DNA methylation modifications at AIP-associated loci (e.g., APOA5, LPL) in females are significantly correlated with systolic blood pressure, whereas no such association is observed in males, Some studies have even suggested that the AIP may serve as a robust independent predictor of coronary artery disease (CAD) risk in Han Chinese postmenopausal women, potentially outperforming conventional lipid parameters (15, 16). This evidence concerns the gene APOA5 and coronary artery disorder.