The ROC curve analysis revealed that AIP (AUC=0.6051, 95% CI:0.5912 to 0.6190, P<0.001), BMI (AUC=0.5801, 95% CI: 0.5658 to 0.5944, P<0.001), TG (AUC=0.5750, 95% CI:0.5596 to 0.5903, P<0.001), HDL-C (AUC=0.5652, 95% CI: 0.5463 to 0.5841, P<0.001), and blood glucose (AUC=0.5643, 95% CI:0.5487 to 0.5799, P<0.001) all had significant impacts on the incidence of pre-hypertension and hypertension in the middle-aged and elderly population. This evidence concerns the gene AIP and hypertensive disorder.