A combination of search terms was applied pertinent to the topic of obesity pharmacotherapy including “obesity pharmacotherapy”, “GLP-1 receptor agonist”, “semaglutide”, “tirzepatide”, “liraglutide”, “naltrexone/bupropion”, “phentermine/topiramate”, “orlistat”, “retatrutide”, “survodutide”, “weight loss medications”, “Body Mass Index”, “BMI”, “weight management”, “weight loss” and “obesity”. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.