One of the potentially significant factors could be betatrophin, a hormone alternatively referred to as angiopoietin-like protein 8 (ANGPTL8), hepatocellular carcinoma-associated protein (TD26), or lipazin, which is synthesized primarily in the liver and moderately in adipose tissue, adrenal glands, duodenum, and small intestine (10). Here, ANGPTL8 is linked to carcinoma.