ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: It can be assumed that obesity, coexisting with T1D, and its dysregulatory effect on the body may reduce the secretion of betatrophin and accelerate the loss of pancreatic β-cells, manifested by a faster decrease in C-peptide (31), which could imply that maintaining a healthy body weight may contribute to prolonging the residual function of pancreatic cells.