In the detailed analysis excluding subjects with a history of the relevant outcomes, patients with clinically suspected MEN1 had significantly higher cumulative incidences of composite cardiovascular events (HR, 2.26), cancer (HR, 9.46), diabetes mellitus (HR, 7.79), anxiety (HR, 2.44), and depression (HR, 2.79) compared with controls, with no significant difference observed for fractures (HR, 2.50) (Supplementary Figure S3). This evidence concerns the gene MEN1 and major depressive disorder.