Recent research has increasingly utilized albumin as a denominator in prognostic indices for sepsis, such as lactate-to-albumin ratio, C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio, gaining attention for sepsis prognosis in emergency settings (40–42), highlighting its role as a negative acute-phase reactant and a marker of nutritional status. This evidence concerns the gene CRP and Sepsis.