Patients with severe infections (0.94 mmol/L), heart failure (1.025 mmol/L), chronic kidney disease (1.03 mmol/L), fever (0.85 mmol/L), high CRP levels (1.01 mmol/L), and hypoalbuminemia (0.91 mmol/L) had significantly lower HDL-C levels compared to those without these conditions. This evidence concerns the gene CRP and heart failure.