For patients with disease burdens or in inflammatory states, the risk of low HDL-C was significantly increased by 2.496 times in those with severe infections, 1.543 times in those with chronic kidney disease, 3.056 times in those with fever, 1.794 times in those with high CRP, and 2.703 times in those with hypoalbuminemia. The gene discussed is CRP; the disease is infection.