ALOX12 and cancer: Additionally, in mouse breast cancer models, sucrose-rich diets have been found to upregulate 12-lipoxygenase (12-LOX) and its arachidonic acid metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), which have been linked to increased cancer cell invasiveness and metastatic potential (46).