This study aimed to assess the diagnostic efficacy of the PRIMARY score, based on the 18F-labeled prostate-specific membrane antigen (PSMA-1007) positron emission tomography (PET)/computed tomography (CT) with multiparametric magnetic resonance imaging (mpMRI) PI-RADS, in detecting clinically significant prostate cancer (csPCa). This evidence concerns the gene FOLH1 and Familial prostate cancer.