(51) shows that the hypoxia response is specifically enriched in a large series of human ALK-positive lymphoma and NSCLC cases, and they provide evidence that ALK specifically regulates the expression of HIF1α and HIF2α under hypoxic conditions in both anaplastic large-cell lymphoma and NSCLC, and that both HIF1α and HIF2α are essential for NSCLC growth and metastasis. Here, ALK is linked to anaplastic large cell lymphoma.