IL-6 mediated 5 % of the association of T2DM with Aß40 ([1.5 %–10 %], p-value<2 × 10−16), 4 % with Aß42 ([0.7 %–11 %], p-value = 0.014), 8 % with TMT-B ([0.2 %–35 %], p-value = 0.046), 11 % with total Tau ([2.5 %–40 %], p-value = 0.010), 5 % with NfL ([1.6 %–8 %], p-value<2 × 10−16), and 12 % Hippocampus atrophy ([3 %–49 %], p-value = 0.004). This evidence concerns the gene IL6 and type 2 diabetes mellitus.