The dissociations observed between T2DM and non-T2DM groups in the IL-6-based associative analyses might indicate a beneficial effect of mediation, healthy diet, and physical activity, as most participants with T2DM seem to be compliant with at least one of these protective factors, and this hypothesis needs to be explored by larger interventional and registry/population-based studies. This evidence concerns the gene IL6 and type 2 diabetes mellitus.