Moreover, at the behavioral level, loss of Cbln1 has been associated with impairments in fear memory and spatial learning (Lu et al., 2024; Otsuka et al., 2016), while loss of Baiap3 is implicated in the development of anxiety and depression (Kim et al., 2021; Wojcik et al., 2013). Here, CBLN1 is linked to depressive disorder.