UBE3A and Cognitive impairment: In line with these findings, both the loss and duplication of Ube3a and Mecp2 have also been associated with the development of cognitive impairment and memory deficits in mice (Collins and Neul, 2022; Smith et al., 2011; Tian et al., 2024; Copping et al., 2017; Godavarthi et al., 2012; Jamal et al., 2017; Robinson and Pozzo-Miller, 2019; Su et al., 2023).