NEXMIF and microcephaly: In our previous work, we found that patients with a loss of expression of the X-linked gene NEXMIF (also known as Xpn, KIAA2022, or KIDLIA) display ID and ASD characteristics, including repetitive behaviors, social deficits, and a limited or lack of language capability accompanied by seizures and microcephaly (Van Maldergem et al., 2013).