Previous studies have demonstrated that Sgk1 upregulation in mice is associated with neurodegeneration, impairments in learning and memory, and anxiety- and depressive-like behaviors (Elahi et al., 2021; Lang et al., 2006; Lang et al., 2010; Liu et al., 2021; Sato et al., 2008), which may contribute to the development of these deficits in NEXOX mice. Here, SGK1 is linked to Anxiety.