Prevotella possesses the ability to dehydroxylate primary bile acids to generate secondary bile acids, such as deoxycholic acid, and other products, the latter of which exacerbate insulin resistance by inhibiting GLP-1 secretion via the farnesol X receptor (FXR) (Kong et al., 2019; Su et al., 2022). This evidence concerns the gene NR1H4 and Insulin resistance.