Compared with the control group, the blood glucose of diabetic PD mice increased, and the total distance and resting time in the central area decreased in the open field tests, stride length and overall run speed reduced in the gait analysis experiments, stance time and stride width increased, and the levels of necroptosis-related proteins such as TNF-α and RIP1, as well as neuroinflammation-related proteins including NF-κB p-p65/p65, IL-1β, and MCP-1 increased. This evidence concerns the gene IL1B and Parkinson disease.