IL1B and Parkinson disease: There is evidence that the concentrations of TNF-α, IL-1β, MCP-1, IL-2, and IL-6 increased significantly in the peripheral blood of PD patients (Qin et al., 2016; Santaella et al., 2020), inflammatory factor administration of IL-1β aggravated DA neuron loss in PD rats (Pott Godoy et al., 2008).