CCL2 and Parkinson disease: In addition, compared with the control group, the content of the pathological protein α-syn in the brains of diabetic PD mice increased, the content of TH decreased, the expressions of necroptosis-related proteins TNF-α and RIP1 increased, and the levels of NF-κB p-p65/p65, IL-1β, and MCP-1 in the NF-κB inflammatory pathway increased.