SERPINB5 and hepatocellular carcinoma: Then, the rescue experiments demonstrated that ferroptosis-related biomarkers, such as the MDA and ROS levels, the GSH/GSSG ratio, the degree of lipid peroxidation, and the damage degree of mitochondrial morphology, were reversed in in-016975 + si-Maspin cotreated sorafenib-resistant HCC cells, unveiling that Maspin was actually involved in hsa_piR_016975-induced sorafenib resistance by regulating ferroptosis in HCC.