The serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and α fetoprotein (AFP) levels were much lower in the in-016975/Sora@PLGA-CM treatment group than in the Sora@PLGA-CM and in-016975@PLGA-CM treatment groups, revealing its notable therapeutic effects on HCC (Fig. 9B to E). Here, AFP is linked to hepatocellular carcinoma.