The indel variant c.1006-44_1007delinsATTTTG is suggested to involve a functionally critical region because RYR2 variants associated with CPVT are clustered within four mutational hotspots, including exons 3–15, 44–50, 83–90, and 93–105 (Steinberg et al., 2023). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.