RYR2 and catecholaminergic polymorphic ventricular tachycardia: CPVT is associated with several genes, including RYR2, CASQ2, CALM1, CALM2, CALM3, KCNJ2, TECRL, and TRDN, where RYR2-related CPVT accounts for 60%–70% of all cases (Wilde et al., 2022).