The CXC chemokine is a complex system, and it has been confirmed that the levels of factors such as CXCL8, CXCL2, and CXCL8 are significantly elevated in gout patients (Wang et al., 2024), among which CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, leading to inflammatory responses and pain in gouty arthritis (Yin et al., 2024); CXCL2 is associated with inducing neutrophil migration (Ryckman et al., 2003). Here, CXCR2 is linked to gout.