PTGS2 and gout: Studies have shown that the inflammatory response of gout is driven by neutrophils and inflammatory monocytes, which self-sustain local inflammatory responses and maintain inflammatory cycles by activating the preferential coupling of the inducible enzymes COX-2/mPGES-1 and the regulation of PPARγ, while IL-17A neutralizing antibodies can affect this process (Saviano et al., 2022).