Among them, CXCL8 and PTGS2 had significant positive correlations with M2 macrophages and activated mast cells, IL10 had significant positive correlations with M2 macrophages and T cells gamma delta, and CXCL8, PTGS2 and IL10 had significant negative correlations with resting CD4 memory T cells, resting NK cells and naive CD4 T cells (P < 0.05) (Figures 7E–G), suggesting that key genes may play an important role in the occurrence and development of gout by regulating these immune cells. This evidence concerns the gene IL10 and gout.