PCLAF and gout: In gout, monosodium urate crystals can induce the production of IL-8, which binds to the CXCR-2 receptor, leading to the recruitment and activation of neutrophils, and the production of inflammatory mediators such as leukotriene B4 (LTB4) and platelet-activating factor (PAF), exacerbating the inflammatory response of gout (Terkeltaub et al., 1998).