CXCL8 and gout: In summary, this study adopted a strategy of integrating multi-omics data analysis to systematically explain the key roles and regulatory mechanisms of CXCL8, PTGS2, and IL10 in the pathogenesis of gout, which not only deepens the understanding of the pathogenesis of gout, but also provides new ideas and potential targets for developing molecular diagnostic markers and new treatment strategies for gout.