CD4 and gout: Among them, CXCL8 and PTGS2 had significant positive correlations with M2 macrophages and activated mast cells, IL10 had significant positive correlations with M2 macrophages and T cells gamma delta, and CXCL8, PTGS2 and IL10 had significant negative correlations with resting CD4 memory T cells, resting NK cells and naive CD4 T cells (P < 0.05) (Figures 7E–G), suggesting that key genes may play an important role in the occurrence and development of gout by regulating these immune cells.