Mechanistic dissection identifies that Catalpol significantly promotes stroke angiogenesis, promotes the proliferation and differentiation of NSCs in the subventricular zone, and prevents neuronal loss and astrocyte activation in the ischemic cortex or the dentate gyrus of the hippocampus in vivo, through a mechanism mediated by activation of the VEGF-A/KDR pathway (S et al., 2023). This evidence concerns the gene VEGFA and Stroke.