Previous studies have also demonstrated that activation of the Ang-(1-7)/Mas receptor axis regulates NLRP3 activation in several inflammatory models, including hepatic fibrosis (Zhang et al., 2016), neuroinflammation (Duan et al., 2021), vascular senescence (Romero et al., 2019), and pulmonary inflammation (Zhang et al., 2016; Sun et al., 2017; Huang et al., 2020). This evidence concerns the gene NLRP3 and Hepatic fibrosis.