Coptisine induces apoptosis in HCT-116 cells via the PI3K-AKT and mitochondria-associated apoptosis pathway (Chai et al., 2024; Yang et al., 2024), and cinnamaldehyde inhibits the progression of ovarian cancer via the PI3K-AKT pathway (Bai et al., 2023; Kim et al., 2022). The gene discussed is AKT1; the disease is ovarian carcinoma.