To the best of our knowledge, this is the first study to demonstrate that the deacetylation of CPT1A histones by SIRT2 may regulate the progression of periodontitis by suppressing the activation of the MAPK and NF-κB signaling pathways, thereby inhibiting osteoclast differentiation and minimizing the production of inflammatory factors (Figure 7). This evidence concerns the gene NFKB1 and periodontitis.