ACLY and hepatocellular carcinoma: For example, MYC, a SE-driven oncogene in HCC, simultaneously activates glucose transporter 1 (GLUT1) to enhance glycolysis and upregulates ATP-citrate lyase (ACLY) to promote lipid biosynthesis by converting glycolytic intermediates into acetyl-CoA (Liu Y. et al., 2024; Guo et al., 2023).