They further identified several critical compositions of the trans-acting SE complex—CDK7, BRD4, EP300, and MED1-that were frequently overexpressed in human HCCs and were associated with the poor prognosis of patients with HCC (Zhang et al., 2019; Pei et al., 2023; Chang et al., 2019; Chen et al., 2021). The gene discussed is EP300; the disease is hepatocellular carcinoma.