HCCL5 as a crucial oncogene in HCC, promoting G1-S transition, cell growth, invasion, and even metastasis; LINC01004 promoted cell proliferation and metastasis of HCC, mediated by of E2F1 to the SE; LINC01089 forms an epigenetic network to promote the HCC metastasis. Here, E2F1 is linked to hepatocellular carcinoma.