Recently, Peng’s group identified a novel lncRNA, named fatty acid synthesis-related lncRNA (FASRL), through binding to acetyl-CoA carboxylase 1 (ACACA) to increase fatty acid synthesis and lipid accumulation and finally exacerbate HCC (Peng et al., 2022). The gene discussed is NQO1-DT; the disease is hepatocellular carcinoma.