SIRT7 and metabolic dysfunction-associated steatotic liver disease: Through integrating epigenomic profiling of NAFLD-associated HCCs, Wu et al. revealed a compendium of SE-activated chromatin regulators, pointing out that Sirtuin 7 (SIRT7) SE-driven tumor-suppressor silencing is associated with metabolic and immune dysfunction for tumor progression (Wu et al., 2022).