Ang II increases arterial pressure by inducing vasoconstriction and promoting sodium and water reuptake in the renal tubules (Failer et al., 2022), promotes systemic arteriole constriction, causes hypertension by binding to Ang II type I receptors, and contributes to fibrosis in hypertension-related heart disease (Funck et al., 1997; Maning et al., 2017). The gene discussed is AGT; the disease is hypertensive disorder.