In models of severe acute pancreatitis and sepsis, calycosin downregulates HMGB1 expression, suppresses NF-κB p65 phosphorylation and MyD88/NF-κB signaling, and alleviates histopathological damage (Chen et al., 2021; Zhu et al., 2021a). This evidence concerns the gene NFKB1 and Sepsis.