Similarly, the Ma DC et al. study (Ma et al., 2021a) showed that pre-administration of salvianolic acids enhances neuron survival by altering microglial polarization from M1 to M2, thus suppressing the NLRP3 inflammasome/pyroptosis pathway in both laboratory and live models of brain ischemia-reperfusion injury. The gene discussed is NLRP3; the disease is brain ischemia.