NEFL and hypertensive disorder: Figure 6 showed the pathways between VLSFAs, NfL, and hypertension with labels indicating their positive or negative associations. The indirect effects through hypertension accounted for approximately 18.4% of the association between C22:0 and NfL, 15.0% between C23:0 and NfL, and 20.1% between C24:0 and NfL (all p values for mediation < 0.001).