Further analysis in this study indicated that bone marrow plasma cell count, Vit D, and IL-6 all have certain prognostic value in MM, and combined detection can improve the sensitivity and specificity for prognosis, reaching 79.9 and 79.5%, respectively, with an AUC of 0.835 (0.741–0.928). This evidence concerns the gene IL6 and Miyoshi myopathy.