Also, Pregnancy Zone Protein (PZP), Inter-Alpha-Trypsin Inhibitor Heavy Chain 3 (ITIH3), and C4 binding protein (C4BP) expression were significantly higher at end-stage BOS in patients with BOS when compared to patients with non-BOS (FDR < 0.1). Here, ITIH3 is linked to Buschke-Ollendorff syndrome.