CHL1 and Buschke-Ollendorff syndrome: Three months before BOS onset, neural cell adhesion molecule L1-like protein (NCHL1), human type II Keratin-6 (K2C6A) and centromere protein F (CENPF) were lower in patients with BOS compared to patients with non-BOS patients(FDR < 0.1, Figure 7, Table 2).