Recent studies have found that abnormal POF1B expression plays a significant role in the progression, invasion, and prognosis of squamous cell carcinoma, mucinous ovarian tumors, colorectal cancer, bladder cancer, and lung adenocarcinoma (Bech et al., 2023; Zhang et al., 2023; Wang et al., 2021; Furtado et al., 2024; Ojeda et al., 2011). Here, POF1B is linked to colorectal cancer.