In addition, the screened DAMs, including prostaglandin F3a and N-methyl-2-oxoglutaramate, and their enriched pathways of steroid hormone biosynthesis; PPAR signaling pathway; linoleic acid metabolism; histidine metabolism; and alanine, aspartate, and glutamate metabolism, may participate in the occurrence and progression of ROP. This evidence concerns the gene PPARA and retinopathy of prematurity.