Based on model 3, which adjusted for potential confounders including age, sex, smoking, diabetes, hypertension, COPD, atrial fibrillation, HbA1c, eGFR, HDL-c, LDL-c, WBC, CRP, UA, and TG, we performed smooth curve fitting and threshold effect analysis to examine the relationship between SII and NIHSS. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.