For example, Kamsteeg et al (2011) developed HSE models that mimic AD conditions using cells from healthy donors or patients with AD and supplementing the organotypic skin models with T helper 2 cytokines, IL-4 and IL-13, whereas van den Bogaard et al (2014) reported the development of an HSE model with keratinocytes and T cells. This evidence concerns the gene IL13 and Alzheimer disease.