Several autophagy modulators, including curcumin and rapamycin (mammalian target of rapamycin (mTOR) inhibitors) and resveratrol and metformin, (AMP-activated protein kinase activators), have been studied in AD animal models and shown to be safe in various phases of clinical trials, despite being initially developed for treating conditions other than AD.36 This evidence concerns the gene MTOR and Alzheimer disease.