MAPT and diabetes mellitus: We observed an increase in p-tau levels (two-way ANOVA: amylin factor, F(1, 27) = 7.377, P< 0.05; diabetes factor, F(1, 27) = 3.242, P = 0.08; interaction, F(1, 27) = 6.148, P< 0.05) in the visual cortex of AMY/STZ compared with all groups (Šídák's test: CIT/PBS, P < 0.05; STZ/PBS, P< 0.01; CIT/AMY, P< 0.05) (Fig. 6B).