MAPT and Insulin resistance: Recent evidence has led to the emergence of the concept that AD represents a brain type of diabetes, also referred to as type 3 diabetes, since AD and diabetes share many pathological features, such as insulin resistance, memory impairment, neuroinflammation, and protein misfolding.3, 4, 5 From this perspective, there is a growing interest in investigating the roles of β-amyloid, tau, and amylin in the brain and peripheral organs, as well as potential cross-seeding mechanisms between the protein aggregates.3