It has been reported that amylin structurally interacts with tau and contributes to its aggregation.21, 22, 23, 24 The injection of co-aggregates of tau and amylin into the hippocampus of PS19 mice induced more severe tauopathy along with increased synaptic and cognitive impairments compared with the effects of tau injection alone.21 Here, MAPT is linked to Cognitive impairment.