IAPP and Cognitive impairment: ,10 Moreover, amylin oligomers participate in a cross-seeding interaction with β-amyloid peptides, which accumulate in brain senile plaques, a hallmark of AD.11, 12, 13 Like β-amyloid, amylin aggregates trigger several AD-related pathological mechanisms, including mitochondrial dysfunction,13 neuroinflammation, and cognitive deficits.14