The accumulation of p-tau disrupts microtubule stabilization, leading to the formation of neurofibrillary tangles, which is closely linked to synaptic dysfunction, memory impairments, and cell death in AD and diabetes.16, 17, 18, 19, 20 Evidence suggests that amylin can interact with tau protein and potentially worsen tau pathology.21, 22, 23, 24 Amylin formed hetero-oligomers with an amyloidogenic cytotoxic tau fragment in vitro,23 and administering amylin increased p-tau levels in primary neurons in a dose-dependent manner.25 This evidence concerns the gene MAPT and diabetes mellitus.