IFNA1 and juvenile idiopathic arthritis: Next, to explore the immune response in JIA patients, enrichment in two GO biological process pathways, namely, response to IFN-α and acute inflammatory response, were assessed in the cell types across the four conditions (Fig. 1E), as the GO enrichment analyses of DEGs in various subpopulations of JIA and HC showed that some of the subpopulations' enrichment results were involved in IFN signaling (Fig. S1).