To further identify the downstream target of NKAPL, bioinformatics analysis was performed to investigate the relationships between NKAPL expression and the top 20 proteins interacting with NKAPL, and the results demonstrated that TRIM21 had the highest correlation with NKAPL expression in NSCLC (Fig. 5C; Fig. S5). This evidence concerns the gene TRIM21 and non-small cell lung carcinoma.