However, ETP-ALL is defined by the absence of CD1a and CD8, weak or absent expression of CD5, and the presence of two or more myeloid or stem cell markers (e.g., CD13, CD33, CD34, CD117, HLA-DR, CD11b), without fulfilling the full criteria for myeloid lineage assignment [2]. This evidence concerns the gene ITGAM and acute lymphoblastic leukemia.